BIOTECHNOLOGY ASSOCIATION
PG and Research Department of Biotechnology
National College (Autonomous)
Tiruchirapalli – 620 001.

Date and Time: 07-08-2018 / 11.00 a.m.                              Venue:  Seminar Hall

Title: “Placental Mechanistic Target of Rapamycin Regulates Fetal Growth”

Biotechnology Association of our College organized a special lecture titled “Placental Mechanistic Target of Rapamycin Regulates Fetal Growth” on 07-08-2018.  The Lecture was delivered by Dr. Fredrick Rosario Joseph, Research Assistant Professor, Director of Obstetrics & Gynaecology, University of Colorado, Colorado. Dr.Fredrick J. Rosario pointed the advantages of pursing research over abroad. He addressed on mechanism on transport of placental folate. With the help of cultured primary human trophoblast cells he tested the hypothesis that mechanistic target of rapamycin complex 1 (mTORC1) and 2 (mTORC2) regulate folate transport by post-translational mechanisms. Silencing raptor (inhibits mTORC1) or rictor (inhibits mTORC2) markedly decreased basal folate uptake. Folate uptake stimulated by insulin + IGF-1 was mediated by mTORC2 but did not involve mTORC1. mTORC1 or mTORC2 silencing markedly decreased the plasma membrane expression of FR-α and RFC transporter isoforms without affecting global protein expression. Inhibition of the ubiquitin ligase Nedd4-2 had no effect on folate transport. In conclusion, they report for the first time that mTORC1/C2 are positive regulators of cellular folate uptake by modulating the cell surface abundance of specific transporter isoforms and the regulation of placental folate transport by mTOR signaling provide a direct link between placental function, gene methylation and fetal programming. Earlier, Dr. M. N. Abubacker, Associate Professor and Head, Department of Biotechnology welcomed the gathering. Mr. S. Sivakumar, Principal In-Charge, delivered the presidential address. Dr. S. Sankaramanivel, Vice-President, Biotechnology Association proposed vote of thanks.


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